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Moreover, selenium plays important biological roles in maintaining thyroid activity, immunity, and homeostasis through the production of oxidoreductases, such as glutathione peroxidases (GPX), iodothyronine deiodinase (DIO) and thioredoxin reductase (TrxR), and the plasma selenium transport protein (SePP1) [75,80], and preventing several pathologies, such as cancer, diabetes, and aging-related diseases, to name a few [241,242,243]

Its naturally produced by the liver and plays a crucial role in the body, from supporting immune function to detoxifying cells

After 24 h, medium was replaced with DMEM/FBS/15 g ml 1 blasticidin/100 g ml 1 hygromycin (DMEM/FBS/B/H), followed by selection for approximately 2 weeks (medium change every 3 d)