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For this reason, they are recognized as a model system for investigating the effect of disease triggers such as hyperglycemia, oxidative stress, and hypoxia on the endothelium, as well as angiogenesis, and cellular immune responses mediated by leukocytes [83,84,85,86,87]

In this context, recent studies have shown that in colostrum and mature milk, IL-2, IL-10, and IFN- are higher at night, while IL-6 and TNF- are higher during the day, exhibiting circadian rhythms