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In simple terms, KPV is the short three-amino-acid fragment that researchers have studied as a more focused inflammation-related peptide signal

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doi: 10.3390/ph16071020

According to studies, it can enhance sleep efficiency, restore circadian rhythms, and improve the quality of sleep without sedation or drowsiness the following day

Consequently, it is of major clinical significance to develop a biomaterial capable of inhibiting ferroptosis and inflammation of degenerative NPCs via reducing excessive ROS accumulation in the microenvironment, thereby restoring NPC viability and ECM homeostasis to promote disc repair, which would perform promising therapeutic efficacy on IDD