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In this review, we evaluate evidence positioning T-cell dysfunction as a central determinant of therapeutic durability, dissect the mechanisms driving both effector exhaustion and memory failure, and discuss how this integrated understanding is informing next-generation combinatorial immunotherapies

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[DOI] [PMC free article] [PubMed] [Google Scholar] Guskiewicz KM, Marshall SW, Bailes J, McCrea M, Cantu RC, Randolph C, Jordan BD (2005) Association between recurrent concussion and late-life cognitive impairment in retired professional football players