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Under the control of the biological clock system, the heterodimer CLOCK/BMAL1 and a series of other transcription factors are responsible for the circadian oscillation of gene expression ( PER1 , PER2 , and PER3 ), and Cryptochromes ( CRY1 and CRY2 )

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After incubation for another 30 min, the cells were stained with Hoechst (1 g mL 1 ) and JC-1 (1 g mL 1 )

Collectively, studies indicate that miRNAs play a multifaceted role in tumor immune escape by exerting an impact on both the processes of tumor cells and the functions of immune cells