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International union of basic and clinical pharmacology

2024;163 doi: 10.1016/j.neubiorev.2024.105774

This medication has been explored as a therapeutic option for PD due to its inhibitory effects both on the release of transforming growth factor (TGF) from fibroblasts and TGF-receptors

[ 14 ] BACH1 can also recruit a histone H3K4me1/2 demethylase named lysinespecific demethylase 2 (LSD2), bind to p53 R175H and form BACH1p53 R175H LSD2 complex, which modifies histone methylation status at the promoter of BACH1 targets and subsequently activates the genes transcription

CA19-9 is the most commonly used biomarker, and a glycoprotein, despite its low specificity and sensitivity, especially in early-stage disease and in patients who lack the Lewis antigen (~510% of the population), which is required for CA19-9 expression