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Due to the intimate connection between oxidative metabolism and myocardial contractility, changes in mitochondrial function could result in reduced oxidative phosphorylation and contractility (15, 16)

L-carnitine: the transporter idea L-carnitine is not a fat itself

the results are summarized in Table 1

The acyl-CoA undergoes sequential -oxidation, generating acetyl-CoA that enters the tricarboxylic acid (TCA) cycle for energy production or converts to ketone bodies in hepatic mitochondria ( Building on these mechanistic insights, Clinical observations support carnitine's metabolic relevance in fatty liver disease, as NASH patients show significantly reduced serum L-carnitine levels compared with healthy controls ( Preclinical investigations consistently demonstrate that L-carnitine supplementation ameliorates metabolic disturbances in experimental NAFLD/NASH models

11 By contrast, inadvertent acute ingestions of thyroid hormone usually manifest only minor toxicity