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In rare cases, they can be serious and might mean stopping the supplement

Proc Soc Exp Biol Med 115:725728 Arisawa T, Harata M, Kamiya Y, Shibata T, Nagasaka M, Nakamura M, Fujita H, Hasegawa S, Nakamura M, Mizuno T, Tahara T, Ohta Y, Nakano H (2006) Is omeprazole or misoprostol superior for improving indomethacin-induced delayed maturation of granulation tissue in rat gastric ulcers

Its known to be the most effective way to treat a deficiency simultaneously