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Although further dose-optimization studies are warranted to maximize the antiviral effect in the lower respiratory tract, phenformin showed antiviral activity in the upper respiratory tract, the main anatomic site for viral entry and spread

JAMA 315, 801810

4 BongiovanniM.SpitaleA.FaquinW

Accordingly, we observed that DMF significantly increased mRNA expression of myelin proteolipid protein 1 ( Plp1 ) in differentiating neonatal rat OPCs (Fig