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Orthopaedic Surgery 14 (7), 12711280

A study by Allen et al

Thinning areas fill in

Following delivery of a therapeutic dose of paracetamol to a healthy person, the majority of paracetamol is directly conjugated in the liver by phase II enzymes to form glucuronide (APAP-glu) and sulphate (APAP-sul) derivatives

In five prospective randomized controlled clinical trials involving 3711 patients with non-rheumatic AF, warfarin significantly reduced the risk of systemic thromboembolism including stroke (See Table 2)