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These methods facilitate the integration of diverse organic constituents into the silica matrix, resulting in materials with customized properties ( 3.4.4 Stimuli-responsive nanoparticles: external and internal stimuli 3.4.4.1 External stimuli: thermal, magnetic, ultrasound, and light stimuli External stimuli such as thermal, magnetic, electronic, ultrasound, and light can influence the behavior of nanocarriers in biological systems, facilitating controlled release, intracellular drug delivery, and cancer treatment