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Although current evidence supports a sophisticated mechanistic framework linking lactate-mediated hepcidin induction to ferroptosis, the tissue- and cell-type-specific effects of elevated lactate levels induced by diverse physiological and pathophysiological processes on iron homeostasis and ferroptosis throughout the body warrant further investigation

doi: 10.1016/j.jdent.2024.104831

Berberine protects secondary injury in mice with traumatic brain injury through anti-oxidative and anti-inflammatory modulation

In xenograft pulmonary metastasis models, knockdown of IGF2BP3 in MDA-MB-231-Edr and MDA-MB-468-Edr cells reduced lung metastasis, whereas PLSCR1 overexpression reinstated metastatic capacity (Fig

For quantitative real-time PCR (qPCR), the qPCR mixture, comprising cDNA, SYBR Green master mix (Takara Bio, Dalian, China), and primers, was prepared and amplified using a QuantStudio 7 Flex Real-Time PCR System (Life Technologies, USA)