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Furthermore, Nrf2 promoter hypermethylation is observed in both COPD patients and CSE-treated HBE cells, resulting in NRF2 downregulation, inhibited GPX4 expression and ferroptosis occurrence[21]

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Int J Mol Sci 21(13):4760 Kaur K, Saxena A, Debnath I, OBrien JL, Ajami NJ, Auchtung TA, Petrosino JF, Sougiannis A-J, Depaep S, Chumanevich A, Gummadidala PM, Omebeyinje MH, Banerjee S, Chatzistamou I, Chakraborty P, Fayad R, Berger FG, Carson JA, Chanda A (2018) Antibiotic-mediated bacteriome depletion in Apc Min/+ mice is associated with reduction in mucus-producing goblet cells and increased colorectal cancer progression