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This relates to the Arg paradox, a phenomenon where exogenous L-Arg leads to NO-mediated biological effects even though NOS, which utilizes L-Arg as a substrate, is saturated (161)

Zhang Y, Wang X, Li W, Yang Y, Wu Z, Lyu Y, Yue C (2023) Intestinal microbiota: a new perspective on delaying aging

doi: 10.1016/j.euroneuro.2015.12.039

In macrophages, for example, lactylation of proteins such as Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta (IB) enhances their stability or transcriptional co-activator capacity, thereby boosting the production of cytokines like IL-6 and IL-12 (58)

This substantial concentration is explained by its vital role in various physiological processes within the cells that determine overall health