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The absence of controlled long-term data means individual biomarker tracking is the only way to detect subclinical effects early

However, excessive ammonia accumulation induces a novel form of cell death in effector T cells, termed Ammonia death ( Distinct from traditional cell death mechanisms such as apoptosis, necrosis, and pyroptosis, ammonia-induced cell death (termed Ammonia death) is a novel form of cell death triggered by overload of glutamine-derived ammonia, leading to the demise of effector T cells

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