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Acknowledgements This work was financially supported by the National Natural Science Foundation of China (81870423 and 82073914), the Major Project of the Natural Science Research of Jiangsu Higher Education Institutions (19KJA310005), the Open Project of Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica (JKLPSE202005, JKLPSE201815, and JKLPSE 201804), the Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), and the Postgraduate Research & Practice Innovation Program of Jiangsu Province (SJCX20_0536 and KYCX20_1493)

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119 The only currently approved selective IGF-1R inhibitor is teprotumumab, a fully humanized IGF-1R monoclonal antibody, which is used to treat thyroid eye disease