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(55) further demonstrated that in models of PD and other neurodegenerative diseases, EGCG exerts neuroprotective effects via NF-B signaling inhibition by blocking IB phosphorylation and suppressing p65 nuclear translocation, thus downregulating pro-inflammatory cytokines such as TNF- and IL-1 and reducing dopaminergic neuronal loss and motor dysfunction

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In recent years, alternatives have been investigated to reduce or replace FBS in mammalian cell culture