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KFS/VET-IACUC/229/2022)

Additionally, another study demonstrated that AS-IV upregulates p-Akt/Akt and Bcl-2 expression in a concentration-dependent manner while downregulating pro-apoptotic proteins such as Bax and caspase-3, thereby mitigating I/R-induced apoptosis (Jia-lin et al., 2017)

[1] [2] These medications work by mimicking the action of naturally occurring incretin hormones that the body produces in response to food intake

In conclusion, findings from the present study are the first to suggest a plausible role of CB 1 receptor in mediating the dose-dependent cognitive impairments after chronic high-dose mitragynine