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Oxidative stress occurs when there's an imbalance between free radicals (unstable molecules that damage cells) and antioxidants (the molecules that neutralize them)

The authors of the same publication suggest this could be attributed to increased food intake and improved nutrient digestibility

[DOI] [PubMed] [Google Scholar] 85.Haendeler J, Hoffmann J, Tischler V, Berk BC, Zeiher AM, Dimmeler S

Psychoneuroendocrinology 151:106078 Kim Y (2014) Symposium I prescription pattern in the treatment of bipolar affective disorder: what the real world is like Soni D, Kumar P (2022) GSK-3-mediated regulation of Nrf2/HO-1 signaling as a new therapeutic approach in the treatment of movement disorders

Although vitamin C has relatively low toxicity, high doses of it can cause gastrointestinal disturbances, including diarrhea, cramps, nausea, and vomiting