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Description

This cluster does not appear to have a catalytic role, but rather stabilizes FECHs tertiary and quaternary structure, enabling the formation of the dimer interface 70

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The first bromodomain (BD1) binds to poly-acetylated histones, such as H4K5acK8ac, whereas the second bromodomain (BD2) selects for acetylated non-histone proteins 18,19,20