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W.WagemakersL.SchoutenA.van KanJ

In an effort to evaluate the signaling mechanism responsible for the observed cardioprotection, they demonstrated that exogenous H 2 S ameliorated myocardial ischemia-reperfusion injury in db/db diabetic mice by activating Nrf2 signaling in an ERK1/2-dependent manner (Peake et al., 2013)