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In a smaller, double-blind, placebo-controlled trial in 256 older adults, ages 60-75 years, co-supplementation with 300 mg/day of all - rac --tocopherol and 400 mg/day of vitamin C for one year reduced a biomarker of oxidative stress (malondialdehyde) but had no effect on cognitive performance measured by the Mini Mental State Examination (MMSE) scoring system (109)

Mechanisms of selective neuronal cell death due to thiamine deficiency