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According to what is stated above, Nrf2 inhibits ferroptosis through multiple pathways

Inhibition of miR-4763-3p expression activates the PI3K/mTOR/Bcl 2 autophagy signaling pathway to ameliorate cognitive decline

Curcumin reverses resistance to gemcitabine through various mechanisms such as inhibiting drug efflux pumps, regulating signaling pathways (such as PI3K/AKT), and inducing specific modes of death (such as ferroptosis) (Namwa et al., 2025

However, a high level of ROS inhibits the occurrence and development of tumors by inducing apoptosis of tumor cells because of their toxic effects [40]