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Besides GSH conjugation, several activities were found to be associated with GSTs in both plant and animal system such as high steroid isomerase activity, leukotriene biosynthesis, formation of oxylipins (precursor of jasmonic acid), double bond cis/trans isomerization, michael addition, mesotrione degradation, dehydroascorbate reduction, non-catalytic ligand binding and transport, signal transduction [5] and protection against ozone damages [6]

The three SSP enzymes (PHGDH, PSAT, and PSPH) are all highly expressed in various cancers to meet the large serine demand for survival (Locasale et al., 2011

Under alkaline conditions, Fe(II) can undergo spontaneous oxidation to Fe(III), creating an environment favorable for vitamin C-enhanced TET activity (Hore et al

Crucially, for the most extensively studied GST polymorphisms, the metabolic impact is profound and counterintuitive

After centrifugation at 13,000 rpm for 10 min at 4C, 200 l of the supernatant was transferred to a new tube and was subjected to acid hydrolysis by adding 600 l 1 M HCl and incubation at 94C for 2 h