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10.1021/acsomega.3c01121 ACS Omega

While Retatrutides primary clinical studies are metabolic in nature, interest from the bodybuilding community reflects curiosity about its broader potential

Hong M, Kim JH, Han JH, Ryu BR, Lim YS, Lim JD, et al

ROS/PI3K/Akt and Wnt/beta-catenin signalings activate HIF-1alpha-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer

Indeed, the European multicenter study coordinated by Graham reports that, whereas basal hyperhomocysteinemia only shows an additive effect with hypercholesterolemia, it has a synergistic effect with both hypertension and smoking on the incidence of atherosclerotic vascular disease (Graham et al, 1997)