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Most insights into these hostmicrobiota interactions come from preclinical models, revealing both the complexity and potential therapeutic opportunities of the gutbrain communication pathways

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Summary: Vitamin B12 deficiency symptoms include persistent fatigue, pins and needles in hands and feet, memory problems, breathlessness, balance difficulties, and mood changes, with neurological damage possible even before anaemia develops

It is present at a diverse range of concentrations (0.110 mM) in nearly all Gram-negative bacteria, some Gram-positive bacteria, and all eukaryotic cells

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