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These results show the perspective on the early prevention and treatment of HD with metformin

As the core component of class III phosphatidylinositol 3-kinase complex I (PtdIns3K) [99], BECN1 triggers different cell death by cooperating with different partners, and it is also a factor for occurrence of ferroptosis [100]

The study included 16 patients with T2DM (seven without complications and nine with microvascular complications), along with eight healthy, age- and sex-matched controls

Immunology 148 , 1321 (2016)

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