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Genetic or pharmacological inhibition of ALDH18A1through knockout, short hairpin RNA delivered using adeno-associated virus (AAV), or the small molecule inhibitor YG1702triggers ferroptosis and impairs both spontaneous and chemically induced hepatocarcinogenesis

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In addition to microvascular changes, retinal neurodegeneration or loss of the retinal pigment epithelium (RPE) also contribute to diabetic retinal damage early in DR, and HG has detrimental effects on RPE cells by producing ROS and decreasing the Gpxs expression (109)

In vivo studies The efficacy of ginger has been shown in several in vivo and in vitro studies (Tables 1, 2)

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