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Oral hydration remains the first-line recommendation for most athletic dehydration, and that guidance applies to teens at least as much as it does to adults

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Therapeutic approaches, such as pharmacological interventions, time-restricted feeding, chronotherapy, phototherapy and time-dependent pharmacology, have shown potential in the treatment of circadian rhythm-related disorders (2124)

Additionally, activated FLSs migrate to the synovial sub-lining layer to promote angiogenesis and exacerbate synovial hyperplasia and bone destruction [103]