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doi: 10.1186/s13568-017-0326-0

As mentioned earlier, Bax and BCL-2 play an opposite role in the regulation of apoptosis and thus the ratio of Bax to BCL-2 is often used as an indicator for apoptosis

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Several of these copperbinding motifs catalyze formation of reactive oxygen species (ROS), which is believed to be involved in these proteins role in neurodegenerative disorders