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In the GI tract, commensals are immunologically protected by the resident Tregs that mediate luminal immunosuppression

( i-k ) Immunoblot of the indicated proteins in FT282 cells with empty vector (EV) or MYC overexpression treated with IDH1 inhibitor ( i ), cultured under glutamine starvation (GS) ( j ), or treated with mildronate ( k ) and supplemented with KG, l-carnitine, or O-acetyl-l-carnitine

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6 Conclusion and perspectives Ferroptosis, a form of programmed cell death characterized by iron-dependent LP, has emerged as a critical factor in CNS injuries