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Compared with other medications, while L-DOPA has a rapid onset of action, its long-term use carries a higher risk of complications

This toxicity is largely attributed to the aberrant association of PQC network components and other metastable proteins with these aggregates, including molecular chaperones, ubiquitin conjugates, proteasome subunits, the transcription coactivator cAMP response elementbinding protein (CREB)binding protein (CBP), the ATPase valosincontaining protein (VCP)/p97, and nonexpanded wild-type ATXN3 [53,54,55,56,57,58]

However, its performance is enhanced when paired with caffeine, which, again, can disrupt your sleep cycle and prevent you from getting some quality sleep

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