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Under non-stress conditions Pap1 localises to the cytoplasm by continual export from the nucleus, a process mediated by the karyopherin Crm1 and the RanGAP Hba1 (Toone et al, 1998)

Apart from its role in the immune system, NADPH is required by the enzyme glutathione reductase to regenerate reduced glutathione, a key endogenous antioxidant that protects cells from oxidative stress [13]

Lin X, Zhan B, Wen S, Li Z, Huang H, Feng J

This sets up a vicious loop: hyperglycemia oxidative stress low GSH worse insulin resistance more hyperglycemia

Autopsies performed on individuals who died from causes other than thyroid cancer have revealed small PTCs in about 10% of cases, and this frequency has not changed since the 1970s