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Amidine derivatives, formed by substituting a guanidine amine with an R group, offer tuneable basicity (p K a 5 to 12) and consistent protonation at the imino nitrogen, with the TRX gemini surfactant outperforming Lipofectamine in transfection efficiency with lower cytotoxicity [98]

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In chronic MPTP-treated primates, clioquinola metal-chelating agentreduces SN iron and ROS levels, attenuates 4-HNE accumulation, and protects DA neurons (274), indicating that iron chelation can serve as a viable strategy for PD intervention by targeting ferroptosis

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23 Age-related oxidative stress affects the nervous, endocrine, and immune systems and may create a vicious cycle involving chronic oxidative stress and inflammation, which support each other, and increase age-related morbidity and mortality