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No cytotoxic effects were observed at concentrations used for stimulating collagen synthesis, antioxidant defense, and tissue repair

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It also impairs endothelial tube formation in vitro, decreases HIF-1 stabilization and nuclear localization under hypoxic conditions, and inhibits MMP-2 and MMP-9 activity

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Furthermore, cisplatin reduces both the protein and mRNA levels of IL-7 in the bone marrow, but Yi qi yang yin tian sui prescription effectively counters this reduction [67]