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After 10 weeks, the high-dose group exhibited significantly higher urate levels, joint deformities, synovial fluid crystal formation, and varying degrees of kidney damage

Regarding safety, a recent literature review of double-blinded RCTs examined the safety and toxicity profiles of turmeric and curcumin in medical applications (237)

Some nutritional approaches are shown in Fig

This is achieved through several mechanisms, such as mitochondrial biogenesis and adaptive thermogenesis

Figure 2 Numerous studies have highlighted the significance of oxidative stress and reduced GSH levels as major risk factors for neurodegenerative lesions in the central nervous system (CNS) across various neurological diseases (Dringen, 2000)