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There is a bidirectional regulatory relationship between mitophagy and inflammation: insufficient mitophagy can initiate inflammation, while reducing inflammation can promote mitophagy [45]

*Must be added to an IV Therapy Drip Therapeutic plasma exchange (TPE) is a cutting-edge medical service that refreshes the patients plasma (the liquid part of the blood) in order to remove particles that are known contributors to disease and accelerated aging

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Fazirsiran was associated with stable pulmonary function, reduced serum Z-AAT, improved laboratory measures and a safety profile that supports its further clinical development in patients with AATD-LD