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To assess the suppressing effect of VGB4 on PI3K/AKT and MAPK/ERK1/2 signaling pathways, western blot analysis of AKT, p-AKT, ERK1/2 and p-ERK1/2 were performed both in vitro (HUVECs) and in vivo (4T1 tumor tissue sections)

Tucci M, et al

doi: 10.1212/01.wnl.0000140291.86406.d1 65 WilletteAAXuGJohnsonSCBirdsillACJonaitisEMSagerMAet al

Tavoloni N, Reed J, Hruban Z, Boyer J

Its considered an investigational compound in many places and is not universally approved for medical use, but it remains under research for weight-management applications