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S13A), in line with other studies reporting upregulation necroptosis signaling components in human aneurysms[19, 79]

Beyond iron overload, whether iron depletion modulates ferroptosis thresholds by impairing mitochondrial respiratory chain complexesaffecting membrane potential and ROS generationrequires validation using conditional iron transporter knockout, iron chelators, and real-time mitochondrial monitoring (123, 124)