glutathione reductase oxidative stress Mitochondrial in Cellular Redox Homeostasis and Disease Manifestation Role of glutathione in oxidative

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Over time, the genome becomes increasingly dysregulated: DNA regions that should be silent become noisy, protective genes are switched off, and chromatin, the scaffold of DNA wrapped around histones (imagine them like packaging bundles), becomes condensed and brittle, losing its flexibility

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Control of cell state transitions

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