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Because L--glutamyl-p-nitroanilide is disadvantageous for practical use in clinical chemistry testing due to its slight solubility, L--glutamyl-3-carboxy-4-nitroanilide, an alternatively modified substrate, is instead generally favored for easier handling in clinical examinations [85]

The benefits are attributed to N-acetylcysteines mucolytic activity, the ability to restore surface ciliary activity at the nasal epithelium, and modulation of inflammatory response which is central to the immune defence mechanism of nasal mucosa

Koop et al., 2016

Results obtained in our in vitro experiments on GSCs with different degrees of resistance to TMZ confirm that pharmacological inhibition of autophagy results in accumulation of autophagic vacuoles, favoring the cytotoxicity of TMZ