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Potential interactions with drugs metabolized by methyltransferases should be considered

Each option is tailored either for existing or new clients seeking improved health outcomes

We also agree with the commenter that the proposal for calculating the payment limit for a biosimilar for which negative or zero ASP data are reported for all NDCs is dissimilar from the methodology provided in statute for circumstances when positive manufacturer's ASP data is available

However, a high degree of motivation is expected of the research team since its clinical assistance members are those involved in the enrolment process

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