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This higher antibody titer may be attributed to higher dietary Se that is reported to have role in alteration of B-cell development, diversion of Th1/Th2 balance towards Th2, 7,9,23 , ability to reduce oxidative stress, enhancement of antioxidant defenses, and promotion of anti-inflammatory cytokine production 24,55

Hgb, hemoglobin

The hormone hepcidin, elevated in chronic inflammation, binds to ferroportin inducing its internalization and degradation, thereby trapping iron within cells such as macrophages and potentiating pro-ferroptotic microenvironments ( In summary, ferroptosis is profoundly influenced by iron regulatory mechanisms centered on IRP/IRE signaling and ferritinophagy

This allows for a deeper understanding of the specific mechanisms by which astrocytes support synaptic function and maintain overall brain energy homeostasis (Chen et al., 2023)