melanotic schwannian tumor Intradural Schwannoma of the Sacral Spine: An Illustrated Case Report of Diagnostic Conundrum Intracranial malignant melanotic nerve sheath

(2015) described the development of angiotensin IV analogs including Dihexa and their HGF/c-Met potentiation mechanism (PMID: 25455861) Expression of Concern: The landmark 2012 paper describing Dihexa's cognitive effects received an expression of concern from the journal (PMID: 34551989), citing data integrity issues including questioned Western blot images Retraction: A follow-up paper from the same research group was retracted (PMID: 40312093), further undermining the evidence base for Dihexa's reported effects No Human Studies: No clinical trials, pharmacokinetic studies, or safety assessments have been conducted in humans Limited Independent Replication: The core claims about Dihexa's cognitive-enhancing effects have not been independently replicated by groups outside the original laboratory The Evidence Gap: This comparison starkly illustrates the difference between a compound with decades of clinical validation (Cerebrolysin) and one with provocative preclinical data undermined by integrity concerns (Dihexa)

10.7150/ijbs.26111 Int J Biol Sci

The Pep-PEPR ligand-receptor pair is also present in other dicots, such as Solanaceae and Fabaceae (Trivilin et al., 2014

Peripheral neuropathy induced by microtubule-stabilizing agents

10.1074/jbc.M501489200 23 JenningsE