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Interestingly, even in GIST lacking WT KIT, anti-KIT antibodies inhibited tumor growth with an efficacy similar to what we observed in GIST-T1 cells following KITLG immunoneutralization, although the former effect was attributed to increased phagocytosis and stimulation of KIT degradation rather than prevention of KITLG binding [59]

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Other emerging non-canonical regulators include the mevalonate pathway, which generates coenzyme Q10 (CoQ10), an essential cofactor for FSP1

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Not selective