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Ocrelizumab versus interferon beta-1a in relapsing multiple sclerosis

MELATONIN SYNTHESIS AND METABOLISM Melatonin Synthesis Melatonin (N-acetyl-5-methoxytryptamine) is synthesized within the pinealocytes from tryptophan, mostly occurring during the dark phase of the day, when there is a major increase in the activity of serotonin-N-acetyltransferase (arylalkylamine N-acetyltransferase, AA-NAT), responsible for the transformation of 5-hydroxytryptamine (5HT, serotonin) to N-acetylserotonin (NAS) (Figure 1)

managing the complex and often severe immune-related toxicities triggered by inflammatory cell death

SLU-PP-332 and 5-amino-1mq have distinct mechanisms of action