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Iron chelators: Fer-1, a selective ferroptosis inhibitor, reduces ROS and lipid peroxidation, preserves neuronal viability, and improves neurological function in both in vitro and in vivo models (200)

In addition, NF-B-dependent IL-6 expression can also establish a link between ATM, NF-B, and signal transducer and activator of transcription 3 (STAT3) in another pathway (103, 104)

Importantly, emerging evidence supports the existence of distinct PD subtypes, including the so-called body-first (peripheral) and brain-first (central) phenotypes

Three machine learning algorithmsRandom Forest (RF), Gradient Boosting Machine (GBM), and XGBoost (XGB)were developed using the Training Set (Figure, A-C)

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