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But the compounding advantage goes beyond the standard formula

Peripheral-blood exome, genome, and Sanger sequencing to identify pathologic mutations in SOD1 in 4000 patients with ALS from Germany, South Korea, and Sweden has revealed four sporadic ALS cases with de novo mutations in SOD1 , which might be the therapeutic target of ASO [170]

Ishak B, von Glinski A, Dupont G, Lachkar S, Yilmaz E, Iwanaga J, Unterberg A, Oskouian R, Tubbs RS, Chapman JR

Additionally, articles identified through manual searches and from the reference lists of retrieved studies were also included

The MTT solution (0.5 mg/mL) was incubated with cells for 4 h at 37 C and then replaced with 100 L of DMSO to dissolve the formazan product