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Discussion VCD, characterized by an impaired ability to visually perceive and construct complex visual-spatial designs or tasks, is a well-recognized feature of aging-related neurodegenerative diseases, including Alzheimers disease 26

This can occur as a result of: Leaky gut Crohns disease or ulcerative colitis Celiac disease and non-celiac gluten intolerance Small intestinal bacterial overgrowth (SIBO) Certain medications including: NSAIDS (ibuprofen), Antidepressants (Cymbalta, Effexor, Prozac, Zoloft), Antihistamines (Allegra, Benadryl ,Zyrtec), Histamine (H2) blockers (Pepcid, Zantac0, Immune modulators (Enbrel, Humira, Plaquenil), Antiarrhythmics/Calcium channel blockers (amlodipine, diltiazem, propanolol, metoprolol) DAO-blocking foods including alcohol can also lead to decreased availability of DAO to break down histamine, resulting in elevated levels