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The ROS generated from aerobic respiration caused a cumulative oxidative damage in macromolecules, including lipids, DNA, and proteins, which subsequently lead to cells death (Scheibye-Knudsen et al., 2015), and affect the healthspan of numerous principal organ systems (Dai et al., 2014)

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Bulk RNA-sequencing analysis of the hippocampi revealed an enrichment of genes involved in neuronal synaptic plasticity ( homer1 ) 43 , autophagy ( mTOR ) 44 and learning and memory ( igf2r ) 45 in CD38- relative to IgG-injected mice (Supplementary Fig

If redness or irritation persists beyond 2 weeks, discontinue and consult a dermatologist

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